Last updated: October 13, 2026 · By Ronen, Stay Near The Venue
Traveling to Mayo Clinic in Florida for an appointment, a procedure or a longer course of treatment means thinking about more than a room. You want somewhere close to the campus at 4500 San Pablo Rd S in Jacksonville, easy transport and, for longer stays, a kitchen. This guide covers the hotels on and next to the campus, hotels with shuttles, free patient lodging and how parking works.
Quick answer: To be as close as possible, stay on campus at the Hilton Jacksonville at Mayo Clinic (opened October 2025) or the Courtyard Jacksonville at the Mayo Clinic Campus/Beaches. Mayo lists both as offering a free shuttle to the clinic. For longer stays, the Residence Inn Jacksonville-Mayo Clinic Area has in-room kitchens and is less than a mile away. Cancer patients should also ask their care team about the free American Cancer Society Hope Lodge, which is on campus. Patient parking in the main lots is free.
Top hotel picks at a glance
| Hotel | Location & highlights | |
|---|---|---|
| Hilton Jacksonville at Mayo Clinic | on campus at 4745 Transformation Way. This eight-story, 252-room hotel opened on October 1,… | Check price |
| Courtyard Jacksonville at the Mayo Clinic Campus/Beaches | on campus at 14390 Mayo Blvd. It has 146 rooms, an outdoor pool and… | Check price |
| Residence Inn Jacksonville-Mayo Clinic Area | 4905 San Pablo Rd S, less than a mile from the clinic. It opened… | Check price |
| Holiday Inn Express & Suites Jacksonville SE – Med Ctr Area | 4791 Windsor Commons Ct, about 3 miles from campus near J. Turner Butler Blvd.… | Check price |
| Hampton Inn & Suites Jacksonville-Beach Boulevard/Mayo Clinic Area | 13733 Beach Blvd, about 3 miles from Mayo. It has free hot breakfast and… | Check price |
| Hampton Inn Jacksonville Beach/Oceanfront | 1515 N First St, Jacksonville Beach, about 15–20 minutes’ drive from campus. It’s on… | Check price |
Prices change daily – tap “Check price” for live rates on your dates.
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See hotels near Mayo Clinic Jacksonville – compare live rates and filter by kitchen, shuttle or free cancellation.
Hotel map: live prices near Mayo Clinic Jacksonville
Best areas to stay near Mayo Clinic in Florida
| Area | Distance / time | Best for |
|---|---|---|
| Mayo Clinic campus | On site, with free hotel shuttles | Early appointments, limited mobility, surgery stays |
| San Pablo Rd / Beach Blvd | About 1–3 miles, 5–10 min drive | Extended-stay suites, value hotels, grocery runs |
| Jacksonville Beaches | About 6–8 miles, 15–20 min drive | Caregivers who want the ocean between appointments |
| Ponte Vedra Beach | About 8 miles, 15–20 min drive | Quieter resort-style stays |
| Southside / St. Johns Town Center | About 10 miles, 20 min drive | Lots of chain hotels, shopping and restaurants |
On campus
- Hilton Jacksonville at Mayo Clinic – on campus at 4745 Transformation Way. This eight-story, 252-room hotel opened on October 1, 2025. It has the Coastal Kitchen restaurant, a heated outdoor pool and 21 suites, and Mayo lists a free shuttle to the clinic. It’s the most full-service choice for patients and families who want everything in one place.
- Courtyard Jacksonville at the Mayo Clinic Campus/Beaches – on campus at 14390 Mayo Blvd. It has 146 rooms, an outdoor pool and The Bistro for breakfast and dinner, plus free transportation around the campus. Call 904-223-1700 and ask whether a Mayo patient rate is available.
Long stays with kitchens
- Residence Inn Jacksonville-Mayo Clinic Area – 4905 San Pablo Rd S, less than a mile from the clinic. It opened in 2020 and has 155 suites with kitchens, so it’s the practical pick for multi-week treatment or transplant evaluation. It lists free transportation, but check the Mayo shuttle times with the front desk.
With free shuttle
- Holiday Inn Express & Suites Jacksonville SE – Med Ctr Area – 4791 Windsor Commons Ct, about 3 miles from campus near J. Turner Butler Blvd. According to the Joe’s House patient lodging directory, it runs a free shuttle to Mayo Clinic Monday to Friday, 6 a.m. to 6 p.m. A good choice if you won’t have a car.
Best value
- Hampton Inn & Suites Jacksonville-Beach Boulevard/Mayo Clinic Area – 13733 Beach Blvd, about 3 miles from Mayo. It has free hot breakfast and free self-parking. It suits caregivers on a budget who are driving in for a few days.
Near the beach
- Hampton Inn Jacksonville Beach/Oceanfront – 1515 N First St, Jacksonville Beach, about 15–20 minutes’ drive from campus. It’s on Mayo’s area accommodations list and suits families who want an ocean walk at the end of a hard clinic day.
Free and low-cost patient lodging
- Richard M. Schulze Family Foundation Hope Lodge (American Cancer Society) – 4583 Worrall Way, on the Mayo campus. It offers free lodging in 30 private-bath rooms for patients in active outpatient cancer treatment and one caregiver. Your treatment team must refer you (usually a doctor or social worker), and rooms go to whoever is referred first. Guests share a fully equipped community kitchen. Phone 904-674-6640.
- Gabriel House of Care – 4599 Worrall Way, on campus. It provides affordable temporary lodging for adult cancer and organ transplant patients and their caregivers. Call 904-821-8995 for current rates and how to apply.
Getting there, shuttles & parking
Parking: Patients and visitors park free in Patient Parking Lots A, B, C, D and M. A 600-space garage next to the Davis Building charges a small fee, and valet parking is available for a small fee at the front entrance of every patient care building. Mayo has some oversized RV spaces, but they have no hookups and overnight stays aren’t allowed. Wheelchairs are available at the main building entrances.
Shuttles: Mayo says a free shuttle brings guests of its partner hotels and hospitality houses to the front entrance. Some off-campus hotels also run their own shuttles, so confirm times when you book.
Airport: Jacksonville International Airport (JAX) is about 24 miles north of campus, roughly 30–40 minutes by car via I-295 depending on traffic. Most on-campus hotels don’t list an airport shuttle, so plan on a rental car, a taxi or a rideshare.
Sources: Mayo Clinic Florida hotels & lodging, Mayo Clinic Florida parking, Mayo Clinic News Network, American Cancer Society Hope Lodge Jacksonville, Gabriel House of Care.
Tips for patients and caregivers
- When you book, say you’re a Mayo Clinic patient. Mayo notes that some hotels offer patient discounts and shuttles, but rates vary by season and length of stay.
- If your schedule might change after the first consultation, book a refundable or free-cancellation rate. Extra tests are often added with little notice.
- If you’re staying a week or more, a suite with a kitchen saves money and makes special diets easier.
- Apply for Hope Lodge or Gabriel House as early as you can. Space is limited and both need advance contact or a referral.
- Check which building your appointment is in and use the patient lot closest to it. Allow extra time on your first visit.
- Visit Jacksonville runs patient lodging help at 800-733-2668. For extended stays, Mayo also points to vacation rentals.
FAQ
Is there a hotel on the Mayo Clinic Jacksonville campus?
Yes, two. The Hilton Jacksonville at Mayo Clinic (252 rooms, opened October 2025) and the Courtyard Jacksonville at the Mayo Clinic Campus/Beaches are both on campus, and Mayo lists free shuttles for both.
Is parking free at Mayo Clinic in Florida?
Yes, in Patient Parking Lots A, B, C, D and M. The garage next to the Davis Building and the valet service at building entrances charge a small fee.
Is there free lodging for cancer patients at Mayo Clinic Jacksonville?
Yes. The American Cancer Society Hope Lodge on campus offers free rooms to eligible patients in active outpatient cancer treatment and one caregiver. You need a referral from your treatment team.
Which hotels near Mayo Clinic Jacksonville have kitchens?
The Residence Inn Jacksonville-Mayo Clinic Area, less than a mile away, has suites with kitchens. For other options, filter the map above for kitchens or apartments.
How far is Mayo Clinic Jacksonville from the airport?
Jacksonville International Airport (JAX) is about 24 miles away, usually 30–40 minutes by car.
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Getting there and getting around
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We start at the venue and work outward: walking time, shuttle and transit options first, then guest review scores and value for money. Hotels can’t pay to be listed. Some links are affiliate links, so we may earn a small commission at no extra cost to you. Prices and availability change daily, so always check live rates before you book.
