Last updated: October 13, 2026 · By Ronen, Stay Near The Venue
If you or someone you love has appointments at Mayo Clinic in Rochester, Minnesota, where you stay can make long days much easier. Downtown Rochester is built around the clinic, and several hotels connect to the Mayo and Gonda buildings through an indoor skyway and pedestrian subway – so you can get to appointments without stepping outside, even in a Minnesota winter.
Quick answer: choose a skyway- or subway-connected downtown hotel (such as the Kahler Grand, Rochester Marriott, Hilton or Residence Inn) if mobility or weather is a concern. For longer stays on a budget, pick a suite hotel with a kitchen and a free Mayo shuttle.
Top hotel picks at a glance
| Hotel | Location & highlights | |
|---|---|---|
| Kahler Grand Hotel | 20 Second Ave SW; a historic hotel connected to Mayo through a climate-controlled underground… | Check price |
| Rochester Marriott Mayo Clinic Area | 101 First Ave SW; upscale and connected via an underground concourse – very convenient… | Check price |
| Hilton Rochester Mayo Clinic Area | 10 East Center St; skyway-connected to Mayo Clinic and Methodist Hospital. | Check price |
| Hotel Indigo Rochester – Mayo Clinic Area | 220 South Broadway; direct skyway access to the clinic. | Check price |
| Residence Inn Rochester Mayo Clinic Area | 441 W Center St; full kitchens in every room and direct access to Mayo… | Check price |
| Home2 Suites by Hilton Rochester Mayo Clinic Area | kitchenette suites with a shuttle to Mayo and Saint Marys. | Check price |
| TownePlace Suites Rochester Mayo Clinic Area | full kitchens and a shuttle to Mayo locations within about 2 miles. | Check price |
| Hyatt House Rochester Mayo Clinic Area | extended-stay rooms with a shuttle to Mayo and Saint Marys. | Check price |
Prices change daily – tap “Check price” for live rates on your dates.
This article contains affiliate links. If you book through them we may earn a commission at no extra cost to you. Shuttle schedules, rates and parking prices change, so please confirm details with Mayo Clinic and the hotel before you book.
See hotels near Mayo Clinic Rochester
Hotel map: live prices near Mayo Clinic Rochester
Where Mayo Clinic is in Rochester
The main outpatient hub is the Mayo and Gonda Buildings at 200 First Street SW, linked to other buildings and local businesses by underground walkways (the “subway”) and above-ground skyways. Saint Marys Hospital (1216 2nd St SW) is about a mile west of downtown, and Mayo runs a free shuttle between downtown and Saint Marys about every 15 minutes.
Appointment schedules can change, so we suggest booking a room with free cancellation and asking every hotel for its Mayo Clinic patient rate – Mayo notes that many Rochester hotels offer patient discounts.
Best areas to stay
| Area | Distance to Mayo Clinic | Best for |
|---|---|---|
| Downtown, skyway/subway connected | 0–0.2 mi, indoors | Limited mobility, winter, long appointment days |
| Downtown, not connected | ~0.2–0.3 mi or hotel shuttle | Suites, kitchens, lower rates |
| Near Saint Marys Hospital | ~0.6–0.9 mi from downtown | Inpatient stays and surgery families |
| Outer Rochester | 1+ mi, by shuttle | Lowest prices, travelers with a car |
Connected by skyway or subway
- Kahler Grand Hotel – 20 Second Ave SW; a historic hotel connected to Mayo through a climate-controlled underground walkway, with a restaurant on site.
- Rochester Marriott Mayo Clinic Area – 101 First Ave SW; upscale and connected via an underground concourse – very convenient for early appointments.
- Hilton Rochester Mayo Clinic Area – 10 East Center St; skyway-connected to Mayo Clinic and Methodist Hospital.
- Hotel Indigo Rochester – Mayo Clinic Area – 220 South Broadway; direct skyway access to the clinic.
Extended stay with a kitchen
- Residence Inn Rochester Mayo Clinic Area – 441 W Center St; full kitchens in every room and direct access to Mayo via the subway and skyway – the best fit for long stays that also want the indoor connection.
- Home2 Suites by Hilton Rochester Mayo Clinic Area – kitchenette suites with a shuttle to Mayo and Saint Marys.
- TownePlace Suites Rochester Mayo Clinic Area – full kitchens and a shuttle to Mayo locations within about 2 miles.
With free shuttle / near Saint Marys
- Hyatt House Rochester Mayo Clinic Area – extended-stay rooms with a shuttle to Mayo and Saint Marys.
- Staybridge Suites Rochester – across from Saint Marys Hospital, with full kitchens – practical for families during an inpatient stay.
- Courtyard Rochester Mayo Clinic Saint Marys – across from Saint Marys, with a shuttle.
Getting there, shuttles & parking
- Rochester International Airport (RST): about 10 miles south of downtown, with a Mayo information and transportation desk near baggage claim.
- From Minneapolis–St. Paul (MSP): about 80 miles (roughly 90 minutes). Rochester Shuttle Service runs from Terminals 1 and 2 to Rochester hotels and Mayo Clinic in about 95 minutes, from $49 per adult.
- Hotel shuttles: Mayo says nearly all area hotels offer free shuttle service to and from the campus – many run on weekdays only, so check weekend schedules.
- Mayo parking: $2 for the first hour, then $1 per hour, up to $12 per day. Multi-day passes cost $25 (5 days), $40 (10 days) or $75 (25 days). Weekday valet adds $8.
- In town: Rochester Public Transit, taxis, Uber and Lyft are available.
Helpful tips for patients and families
- Always ask for the Mayo Clinic patient rate when booking or checking in.
- In winter or with limited mobility, a connected hotel may mean you don’t need a car at all.
- For stays of a week or more, a kitchen suite saves money and gives you more control over meals.
- Mayo Concierge Services (507-538-8438) and Patient Travel Services (866-551-3392) can help with lodging and travel questions.
- Free or low-cost hospitality houses exist: the American Cancer Society Hope Lodge (for cancer patients in active treatment, by referral), Gift of Life Transplant House, Ronald McDonald House and the Neuro Hospitality House.
Planning a stay of uncertain length
For many families, the hardest part of a Mayo Clinic visit is not knowing how long they will be in Rochester. Appointments, tests, and follow-up visits can change the plan from one day to the next. When you choose a hotel, give weight to flexibility. A rate with free cancellation, or a hotel that lets you extend your stay without penalty, can ease a great deal of stress.
When you book, ask the hotel directly what happens if your stay lengthens or shortens. Some properties offer a weekly or extended-stay arrangement, and some do not. If you are unsure, reserve a few nights first and confirm the details of any longer arrangement once your care team has given you a clearer schedule. Keep your confirmation emails and the hotel’s phone number somewhere easy to find.
Choosing a room that supports rest and recovery
A hotel room becomes more than a place to sleep during a medical trip. It may be where you rest between appointments, take phone calls, eat, and keep medications or supplies organized. Think about what your household needs in practical terms: a quiet room away from elevators and ice machines, a comfortable chair, a desk, a microwave or refrigerator, and room for a travel companion.
Ask the hotel about accessible rooms and entrances if anyone in your party uses a wheelchair, walker, or cane. Ask about step-free routes from the entrance to the elevator and to breakfast areas. If you or a family member will return from appointments tired, a hotel with an easy, short walk from the entrance to the room can matter more than a view. Follow the guidance of your care team about anything health-related; this guide cannot replace it.
Winter weather and packing for Rochester
Rochester, Minnesota, has cold winters, and visitors from warmer places are sometimes surprised by how much the weather shapes a day. In winter, a connected route between hotel and clinic buildings can be a real comfort, and the city is known for an underground subway-style concourse system linking many downtown buildings. If walking outdoors is hard for you, ask whether your hotel connects to that system, and confirm the route with the hotel before you book.
Pack layers, warm footwear with good grip, gloves, and a hat if you travel between late autumn and early spring. Check the forecast before you leave and again the day before each appointment. If you drive, allow extra time on snowy days for clearing the car and finding parking, and ask the hotel what it does about ice at its entrances.
Making the trip easier for companions and caregivers
Many patients travel with a spouse, a parent, an adult child, or a friend, and the companion’s needs matter too. Look for a hotel where a caregiver can prepare simple meals, do laundry, or take a quiet break without going far. Ask about breakfast hours, since early appointments can make a standard window useless, and about nearby grocery options.
Keep a small folder or phone note with appointment times, addresses, medication lists as provided by your care team, insurance details, and hotel contact information. Agree in advance who will handle calls and who will handle logistics, so that nobody has to decide everything under pressure. If a stay becomes emotionally heavy, take advantage of any support services Mayo Clinic or your local care team offers, and do not feel guilty about taking an hour away from the hospital.
Questions to ask before you reserve
A few calm questions before booking can save trouble later. Ask whether the hotel has a shuttle to the clinic and how often it runs, whether the shuttle is accessible, and what time it starts and stops. Ask whether early check-in or luggage storage is possible if you arrive in the morning, and what the rules are for extending a stay.
Also ask about parking, since costs and availability vary, and about the quietest rooms in the building. If you need a room close to the elevator or on a low floor, say so when you book and again at check-in. Write down the answers and keep them with your confirmation, because front desk staff change from one day to the next and a written record helps everyone remember what was agreed.
Mayo Clinic Rochester: how the skyway and subway system works for visitors
Downtown Rochester has above-street walkways (skyways) and underground walkways (subways) that connect buildings, and the local tourism guide notes that they are heated and cooled year-round. Because the network links Mayo Clinic buildings, the guide suggests looking for accommodation connected to the skyway or subway, which can remove the need for a rental car. If you do rent one, you will need to pay for parking at your hotel.
For arrivals, the same guide says Delta and American Airlines provide daily nonstop service to Rochester International Airport from Minneapolis and Chicago, and that hotels vary in what they offer: some run airport transfers from Rochester International, while others offer shuttles from MSP Airport. Between Saint Marys Hospital and the Mayo Building, the clinic provides a shuttle. Ask your hotel which of these it offers before you book.
How we checked this guide
The “Last updated” date at the top of this page is when we last reviewed it end to end.
- Parking rates, shuttle fees and transport times are taken from the port’s, venue’s or operator’s own published pages and from each hotel’s own website — not from aggregator sites.
- Distances and journey times are the figures the venue or transit operator publishes, not our estimates. Where we give a distance, we say what it is measured to.
- Hotel amenities (breakfast, shuttle hours, pet and parking policies) come from each hotel’s own site. These change more often than anything else here, so confirm them when you book.
- Room rates are deliberately not listed anywhere on this site. They move daily, and a price written one month is wrong the next. Our links take you to live pricing instead.
- We have not stayed at every hotel we write about. Where we contacted a property directly, the guide says so and gives the date. Where a figure comes from a third-party report rather than an official source, we say that too.
Found something out of date or wrong? Tell us and we will fix it.
Related guides
- Hotels Near MD Anderson Cancer Center With Shuttles (2027 Guide)
- Hotels Near Memorial Sloan Kettering (MSK) in Manhattan (2027 Guide)
- Hotels Near St. Jude Children’s Research Hospital in Memphis (2027 Guide)
- Hotels Near Cleveland Clinic: Connected, Shuttle – Long-Stay Options (2027 Guide)
- All hospital hotel guides
Official sources: Mayo Clinic official website. Check it for current schedules, transport and ticketing before you book.
FAQ
Which hotels connect to Mayo Clinic indoors?
The Kahler Grand, Rochester Marriott, Hilton Rochester, Hotel Indigo and Residence Inn Rochester Mayo Clinic Area connect via the skyway or pedestrian subway.
Do Rochester hotels offer free shuttles to Mayo Clinic?
Yes. Mayo says nearly all area hotels offer free shuttle service to and from the campus, though schedules vary.
How much does parking at Mayo Clinic cost?
Up to $12 per day, with multi-day passes from $25 for 5 days.
How do I get from MSP airport to Rochester?
Rochester Shuttle Service takes about 95 minutes, with adult fares from $49.
Is there free lodging for cancer patients near Mayo Clinic?
Yes. The American Cancer Society Hope Lodge is free for eligible patients in active treatment and a caregiver, with a referral from the care team.
More venue guides
New: Hotels near Mayo Clinic Jacksonville Also see: Hotels Near Mayo Clinic Arizona (Phoenix & Scottsdale) 2026.
New cancer-center guides: Dana-Farber, Memorial Sloan Kettering, St. Jude.
Also: Hotels near Johns Hopkins Hospital.
Hospital & medical stays: Hotels near MD Anderson Cancer Center, Hotels near Cleveland Clinic. Visiting for a conference instead? See McCormick Place.
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Getting there and getting around
Affiliate links: we may earn a commission at no extra cost to you.
We start at the venue and work outward: walking time, shuttle and transit options first, then guest review scores and value for money. Hotels can’t pay to be listed. Some links are affiliate links, so we may earn a small commission at no extra cost to you. Prices and availability change daily, so always check live rates before you book.
